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In May 2020, a report titled \"The Bio Revolution: Innovation is Transforming Economies, Societies, and People’s Lives\" published by the McKinsey Global Institute (MGI) stated that, in principle, 60% of the material inputs in the global economy could be produced through biological methods. Biotechnology holds tremendous potential for innovation and application in areas such as human health, agriculture, consumer goods and materials, and energy. The editor believes that microorganisms or cells are the unparalleled intelligent factories. The strong and stable proliferative capacity of microorganisms or cell factories, precise and balanced metabolic regulation, as well as a low-carbon and energy-efficient production method are advantages that no artificial intelligence-powered factory can match. Figure 1: Areas of innovation involved in the biological revolution and their direct economic impacts. Image source: “The Biological Revolution: Innovation is Changing Economies, Societies, and People’s Lives.” Over the past decade, thanks to the improvement and optimization of cell lines/strains, as well as the advancement of cultivation equipment and technologies, China has seen rapid progress in innovation and application in health-related fields such as antibodies, recombinant protein-based macromolecule drugs, and vaccines. In 2021, sub-sectors of the pharmaceutical industry such as biopharmaceutical manufacturing, gene-engineered drug production, and vaccine manufacturing generated revenue of 591.8 billion yuan, representing a year-on-year increase of 113.8% ； Profit accounted for 41.7% of the total profit in the pharmaceutical industry, thereby driving the overall development of the sector. Meanwhile, the rapid progress of synthetic biology has enabled those \"microbial factories\" modified through genetic engineering to produce more substances that are traditionally synthesized chemically, such as PHA, BDO, VB2, and others, using biological manufacturing methods. On May 10, 2022, the **National Development and Reform Commission issued the ‘14th Five-Year Plan for the Development of the Bioeconomy’**, which outlines strategies for fostering the bioeconomy sector in four areas: biopharmaceuticals, bioagriculture, bioenergy, and bioinformatics. This plan represents the first top-level strategic document for the development of the bioeconomy in China. The plan suggests that by 2025, the total value of China’s bioeconomy is expected to reach 22 trillion yuan, of which the value of its core industries will exceed 7.5 trillion yuan. In the future, the Beijing-Tianjin-Hebei region, the Yangtze River Delta, the Guangdong-Hong Kong-Macao Greater Bay Area, and the Chengdu-Chongqing economic circle will become national hubs for innovation in the bioeconomy. Figure 2: Key areas emphasized in the 14th Five-Year Plan for the bioeconomy. Although the bioeconomy represents a promising field, it still faces challenges in terms of technology, talent, and related supporting elements. Putting the macro level aside for now, in the process of transforming research into practical applications, technological innovations and industrialization in the fields of pharmaceuticals, agriculture, energy, and environmental protection are all closely related to the selection and improvement of relevant microbial strains or cell lines, the development and scaling up of production processes, technologies and equipment for large-scale cultivation, as well as process analysis and control in biological processes. The variability and uncertainty in bioprocesses are well-known challenges. Whether it is traditional or disposable bioreactors, whether they are small reactors for use on laboratory benches or large fermentation tanks for production, online real-time analysis plays an important role in understanding the process, optimizing it, and thereby enabling stable control of the process to improve the quality and yield of the desired products. Mettler Toledo’s product portfolio for bioprocesses includes sensors and transmitters for measuring various process variables, as well as process connection systems such as sensors for pH/ORP (redox), optical dissolved oxygen, dissolved carbon dioxide, optical density/turbidity, etc., telescopic sensor guards, and automatic sensor cleaning and calibration maintenance systems. Notably, sensors and transmitters are characterized by the use of Intelligent Sensor Management (ISM®) technology. This technology is an innovative digital solution for online process analysis systems; it simplifies sensor operation, improves measurement integrity, and reduces the lifecycle costs of sensors. Figure 3: Analysis and measurement in bioreactors. For over 70 years, Mettler Toledo’s Ingold process analysis and measurement solutions have been widely recognized for silently empowering the development of the biomanufacturing industry. (Compared to hardware investments such as reactors/CIP/SIP and software investments such as process control, process analysis and measurement tend to receive less attention and emphasis in related projects.) To convey more broadly and efficiently our extensive knowledge in bioreactor control strategies, as well as our in-depth understanding of the challenges faced by modern bioprocesses, to end-users in the industry and manufacturers and/or integrators of related equipment, we have compiled the guide titled \"Analytical Measurements in Bioreactors\". The topics covered in this guide include: process analysis solutions in bioprocessing, intelligent sensor management for production, reusable sensors for various types of reactors from R&D to cGMP, and disposable sensors.