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What is the Fuchs reaction mechanism? Please advise, experts

2009-02-05 View Original

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What is the Fuchs reaction mechanism? Please advise, experts
Reply #2 2009-02-05
Fuchs reaction, Friedel-Crafts reaction: Under the action of anhydrous AlCl3, hydrogen atoms on the ring of aromatic hydrocarbons can also be replaced by alkyl and acyl groups. This is a method for preparing alkyl hydrocarbons and aromatic compounds, known as the Friedel–Crafts reaction, abbreviated as the Fischer reaction. Friedel-Crafts reactions do not occur when there are strong electron-withdrawing groups on the benzene ring (such as –NO2, –SO3H). a. Alkylation reaction: Halogenated alkanes generate C+ ions in the presence of AlCl3; before attacking the benzene ring, these C+ ions rearrange into stable C+ ions with three or more carbon atoms. The disadvantage of the alkylation reaction is the occurrence of side reactions. b. Nitration reaction: Acyl halides are commonly used as nitration reagents; anhydrides can also be used. The advantage is that the product is relatively pure.
Reply #3 2009-02-05
Thank you for the answer, 2L; I’ve learned something new again
Reply #4 2009-03-08
Electrophilic substitution reactions, the carbocation mechanism, right?

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