Can organic chemical drugs be degraded?
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As the title suggests, can organic chemical substances have their organic structure destroyed through digestion, so as to meet the sample preparation requirements for ICPMS analysis? If microwave digestion is used, along with reagents such as nitric acid and hydrogen peroxide, can it be ensured that the drugs are completely digested?
This post was last edited by qugd on 2019-7-22 at 21:22. The degradation method using strong oxidizing agents can completely destroy most organic compounds, but for certain special organic substances such as fluorocarbon compounds, perfluoropolymers, perfluoroethers, and some polycyclic compounds containing heteroatoms, it can be very difficult to achieve complete degradation. This requires specific analysis for each compound; there are millions of organic compounds, and without knowing their specific structures and chemical compositions, it is not possible to make generalizations.
Thank you for your reply. Regarding 5,5-diethylbarbituric acid, whose structure is as shown in the figure, can it be completely degraded?
This compound can be digested with nitric acid, but I assume that the nitrides cannot be converted into higher-valent forms; the hydrocarbon elements should be able to be converted into carbon dioxide and water without any problems. Hydrogen peroxide has insufficient oxidizing power and may not be able to degrade it completely.
Well, as you said, if it’s reduced to that extent, even if a complete reduction isn’t possible, can we still ensure that the structure of the organic compounds is damaged enough to meet the requirements for sample introduction in analytical instruments such as ICPMS?
I also want to ask how to determine whether an organic chemical substance has been completely degraded? What instruments or methods can be used to demonstrate it?
Each analyzer has specific requirements for samples; please check the requirements for samples set by the analyzer, or those specified by the analysis method. It can be determined entirely through conditional tests whether it is possible to eliminate something; then why not conduct some such conditional tests?
The instrument requires that liquid samples contain no organic matter. Also, what does a conditional experiment refer to? Could you please explain it? Thank you!
You’d better find some basic materials on analytical chemistry and study them; I don’t have time to answer such fundamental questions.
I’m from a different field, so my questions are rather basic; please don’t mind that\ud83d\ude04