For the same gas chromatograph and under the same operating conditions, does the relative correction factor between the two components change with composition?
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This post was last edited by bcbooo on 2020-11-29 at 22:09. In recent experiments, gas chromatography is needed to determine the components. Therefore, a gas chromatograph was used under exactly the same conditions, and a standard sample with very high purity was employed to determine the relative correction factor. However, it was found that for the two components, the relative correction factors varied under different compositions. The minimum value and the maximum value can differ by 50%, but the overall curve is linear. I checked some books, which state that when two components are analyzed on the same gas chromatograph, the relative correction factors should be the same. I’m really puzzled by this. Have any experienced colleagues encountered this issue? I would appreciate any guidance you can provide.
Is there a component that has exceeded its normal response range, or is there an issue with the detector’s response? It is best to discuss this situation with someone around you who is familiar with chromatography, as it’s difficult to make a judgment based solely on what has been said.
The problem is solved. Indeed, as you said, I used only 2 components to determine the relative correction factor at that time. Later, a third solvent with a relatively large amount was added, and the relative correction factors for those two components became constant.