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Introduction to the Metrohm Automatic Sample Processing System

2008-01-08View Original

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The rapid development of modern chemical industry production has placed increasingly higher demands on product quality control. In modern experimental analysis, a large number of samples need to be analyzed every day; extensive sample preprocessing is required manually, while it is also necessary to ensure that the analysis results are high-quality, precise, and accurate. But in order to cope with the heavy analysis workload, more staff are often added, which ultimately leads to increased labor and management costs. To address these issues, Metrohm has introduced an automatic sample processing system that simplifies tedious tasks. The latest robotic sample processing system introduced by Metrohm automates all sample processing procedures, including liquid aspiration, pipetting, liquid addition, solution preparation, liquid discharge, cleaning, and sample switching, thus making tedious tasks much easier. The system ensures precise and constant liquid addition, accurate sampling, and clean and efficient transfer and discharge of liquids; its reproducibility and work efficiency far exceed those of any previous manual methods. Whether it’s various types of titrations or complex sample preparation, the Metrohm robotic sample handling system is capable of handling all of these tasks. The robotic sample processing system can easily handle large volumes of samples as well as a large number of samples. It enables parallel sample processing, automatic extraction of sample solutions and sample preparation, as well as automatic Karl Fischer moisture determination. This processing system uses three operation methods – keyboard operation, computer operation, and titrator main unit operation. The system features high mechanical movement precision, is reliable, robust, agile, and multifunctional; it has two external titration positions, is manufactured with precision and has a compact design, while its programming is easy to learn and use. The system fully complies with GMP standards as well as the requirements regarding electronic signatures and electronic data storage outlined in FDA 21 CFR Part 11, achieving true automation. Advanced sample preparation techniques for quantitative liquid absorption – the operator can set the exact amount of sample to be taken and the volume of reagents to be added. 800 bottle-top dispensers are used for liquid suction or measurement; thanks to a tube volume resolution of 1/10,000, the accuracy of the 10 ml exchange unit can reach 1 ml. The solution volume, ranging from 0.01 ml to 100 ml, can be accurately quantitatively drawn up. Quantitative addition of reagents and solution preparation: Many analytical methods require further sample processing. For various testing methods that require the use of auxiliary solutions, such as acids or buffer solutions for adjusting pH levels, there are 3 liquid addition devices capable of performing these functions, including the 800 Bottle Top Dispenser or the 805 Automatic Dispenser, which can be controlled directly by the sample processing system. Sample transfer: When transferring a solution from one container to another, the pipetting process of the system boasts extremely high accuracy. This means that while a sample is being analyzed, the sample processor can transfer another sample from the production line to different sample cups on the sample tray at a set time interval. Sample dilution is a time-consuming but unavoidable sample preparation process. In modern analytical methods, the continuous dilution process or the preparation of standard solutions at different concentrations remains important. Whether it is ion chromatography, polarography, ICP analysis, or atomic absorption spectrophotometry, dilution is required. The system can perform these tasks with high precision, its accuracy being far higher than that of volumetric flasks and pipettes. Structure 786 Moving Arm: The 786 moving arm is a precise robotic arm that moves the pipette (sampling tube) into the microtitration cup with millimeter-level accuracy, or automatically retrieves disposable filter heads. The sample is filtered during sampling, and a new filter element is automatically replaced after the sample is arranged. By using the 786 moving arm, it is possible to **increase the number of samples that can be placed on the sample tray. Since the moving arm can extend to multiple rows of sample positions or even beyond the sample tray, the flexibility in the arrangement and positioning of samples is greatly increased. Titration stand: For any titrations to be carried out directly in the sample cup, the titration stand can accommodate 1 type 802 spiral stirrer, 2 electrodes, and 3 titration heads. After the titration is complete, three nozzles are used to rinse the stirrer, electrodes, and titration head, and the rinsing liquid is completely drained to effectively prevent cross-contamination. Replaceable sample trays: Sample trays in various sizes can meet the analysis requirements for different volumes and numbers of samples, and the sample processing system automatically identifies the size of the sample tray. The maximum volume for direct titration is 250 ml, while the maximum volume for external titration can reach 500 ml. The maximum number of samples is 141. Users can order samples with special specifications to meet specific analysis requirements. Lifting work tower: A robust lifting work tower is used to install the moving arm and titration stand, meeting the durability requirements for daily use in laboratories. The titration stand allows for the placement of lightweight electrodes, as well as laboratory instruments weighing up to 3 kg. The liquid suction holder enables complete automation of sample extraction, eliminating the tedious and time-consuming process of measuring samples; it also offers extremely high precision in liquid absorption, operating with an accuracy of 1/10,000 of the tube volume. The external titration sample processing system can not only carry out various tasks within the titration cups of the sample tray, but it can also automatically draw up samples and transfer them to external titration cups. This not only simplifies the sampling process and reduces sampling errors, but also significantly increases the volume of the titration cup. While titrating the sample, the sample processing system can also perform other functions, whether it is parallel titration or the preparation of the next sample. Direct touch screen control: The 814 and 815 model sample processors can be operated directly via a touch screen, without the need to connect to a titrator main unit. This feature allows the sample processor to handle large numbers of samples individually. The automatic sample processing system can be applied in the following fields: ■ Automatic potentiometry. Acid-base titration or the determination of chlorine content are typical examples where automation is needed, especially when a large number of samples must be processed. Whether for simple titrations or complex sample preparation, the sample processor can meet the user’s needs. ■ Water quality analysis: Quality control of drinking water and industrial water, including the determination of pH value, p-value, m-value, chlorine content, as well as calcium and magnesium hardness. ■ Pipetting and measurement in external containers: Pipetting techniques are most suitable for small samples or samples with high concentrations. The sample is transferred to the upper container using a chip-controlled pipetting device for analysis. This requires extremely high precision. (end)

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