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Author of Introduction to Metrohm Automated Sample Processing System: Metrohm, Switzerland The rapid development of modern chemical industrial production has put forward increasingly higher requirements for product quality control. In modern experimental analysis, a large number of samples need to be analyzed every day, and a large number of sample preprocessing must be performed manually. At the same time, it is also necessary to ensure that the analysis results are high, precise and accurate. However, manpower is often added to cope with the heavy analysis work, which ultimately leads to increased manpower and management costs. In response to these problems, Metrohm has launched an automatic sample processing system to make heavy work a breeze. The latest robotic sample processing system launched by Metrohm completely automates all sample processing procedures, including aspiration, pipetting, adding, dispensing, discharging, cleaning, sample conversion, etc., making heavy work a breeze. The system's liquid addition volume is accurate and constant, the sampling volume is accurate, and the pipetting and discharging are clean and neat. Its reproducibility and work efficiency are far better than any previous manual operation. Whether it is various types of titrations or complex sample preparations, Metrohm robotic sample handling systems are up to the job. The robotic sample processing system can easily handle large volume samples and a large number of samples, and can perform parallel sample processing, automatically extract sample solutions and prepare samples, and automatically measure Karl Fischer moisture content. The processing system adopts three operating modes - keyboard operation, computer operation and titrator host operation. The system has high mechanical movement precision, is reliable, sturdy, smart and multi-functional, and has two external titration positions. It is precisely manufactured, compact in structure, and the program operation is easy to learn and use. The system fully complies with GMP specifications and the electronic signature and electronic data storage required by FDA 21 CFR Part 11, truly achieving full automation. Advanced sample preparation technology quantitative pipetting operators can set the accurate sample volume and added reagent volume. 800 bottle top dispenser to perform pipetting or dosing. Since the tube volume has a resolution of 1/10000, that is, the accuracy of the 10ml exchange unit can reach 1ml. The solution volume ranges from 0.01ml to 100ml, and quantitative pipetting can be completed accurately. Quantitative Dosing and Dispensing Many analytical methods require further sample processing. Various assay methods require the use of auxiliary solutions, such as acids or buffer solutions for pH adjustment. There are 3 dosing devices that can perform these functions, including the 800 bottle top dispenser or the 805 automatic dispenser, which can be directly controlled by the sample processing system. Sample Transfer The system's pipetting process delivers extremely high accuracy when transferring solutions from one container to another. This means that while the previous sample is being measured, the sample processor can transfer another sample from the production line to a different sample cup on the sample tray at a set time. Sample Dilution Dilution is a time-consuming but unavoidable sample preparation process. In modern analytical methods, the process of serial dilution or the preparation of standard solutions of different concentrations is still important. Whether it is ion chromatography, polarographic analysis, ICP analysis or atomic absorption spectrometry analysis, dilution is required. The system can complete these tasks with a high degree of accuracy that is far superior to volumetric flasks and pipettes. Structure 786 Moving Arm The 786 Moving Arm is a precision manipulator that moves pipettes (sampling tubes) into microtiter cups or automatically extracts disposable filter tips with mm-level accuracy. The sample is filtered during sampling, and a new filter head is automatically replaced after sampling. Using the 786 mobile arm, you can * * Increase the number of samples placed on the sample tray. Because the mobile arm can extend to multiple rows of sample positions and even beyond the sample tray, the flexibility of sample placement and location is greatly increased. The titration stand performs any titration directly in the sample cup. The titration stand can accommodate a 802 type spiral stirrer, 2 electrodes and 3 titration heads. After the titration is completed, the stirrer, electrode and titration head are rinsed by three nozzles, and the rinse liquid is completely discharged to effectively prevent cross-contamination. Interchangeable sample trays. Various specifications of sample trays can meet the analysis requirements of different volumes and different sample quantities. The sample processing system automatically identifies the sample tray specifications. The maximum volume for direct titration is 250ml, the maximum volume for external titration is up to 500ml, and the maximum sample volume is 141. Users can customize samples with special specifications to meet special analysis requirements. Lifting work tower The sturdy lifting work tower is used to install the mobile arm and titration stand, and meets the durability requirements of daily use in the laboratory. The titration stand can accommodate lightweight electrodes or laboratory instruments weighing up to 3kg. The sample aspiration of the aspiration holder is completely automated, eliminating the cumbersome and time-consuming work of measuring samples, and achieving extremely high aspiration accuracy. It works with an accuracy of 1/10000 of the tube volume. The external titration position sample processing system can not only complete various tasks in the titration cup of the sample tray, but also automatically absorb the sample and transfer it to the external titration cup. This not only simplifies the sampling steps and reduces sampling errors, but also greatly increases the volume of the titration cup. While the sample is being titrated, the sample handling system can also perform other functions, whether parallel titrations or preparation of the next sample. Touch screen direct control Model 814 and 815 sample processors can be directly controlled and operated by the touch screen without connecting to the titrator host. This feature allows the sample processor to handle large batches of samples on its own. Applications Automatic sample processing systems can be used in the following areas: ■ Automated potentiometric acid-base titrations or chlorine content determination are typical examples where automation is required, especially when large numbers of samples need to be processed. Whether used for simple titrations or complex sample preparation, the sample processor can meet the user's needs. ■ Water quality analysis: Quality control of drinking water and industrial water, including pH value determination, p value, m value chlorine content determination, calcium and magnesium hardness determination, etc. ■ Pipetting techniques are best suited for pipetting and measuring small or highly concentrated samples in external containers. The sample is moved to the upper container via a chip-controlled pipetting device and analyzed. This requires extreme precision.