How to get started with the study of macroporous resin adsorption
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I have been working on the extraction of antibiotics. Previously, the method used to reduce Component B in the drugs was extraction followed by back-extraction, but it was difficult to improve the yield. Now the company plans to use macroporous resins for adsorption and separation processes. However, I had no prior knowledge of resin adsorption from my previous work experience, so I need to learn this from scratch. I would like to know where to start learning Are there any materials I can refer to? I hope everyone can offer help. Thank you!
Hydrogen bond adsorption resin: Ordinary adsorption resins rely on van der Waals forces for adsorption, with the adsorption heat ranging from 8 to 20 KJ/mol； The measured adsorption heat of phenol on amide resins ranges from 43.7 KJ/mol to 30.5 KJ/mol; this value is not only much higher than the van der Waals adsorption heat but also falls within the range of hydrogen bond energies (8–50 KJ/mol). The moderate magnitude of the hydrogen bond adsorption heat not only endows the resin with strong adsorption capacity but also allows it to be eluted using common organic solvents. The adsorption of 2,4-***phenol on conventional adsorption resins is greatly influenced by pH; when the pH value increases from 2.5 to 8.5, the adsorption rate drops from 97.2% to 10.7%. When using amide resin for adsorption, the adsorption rate decreased slightly from 99.8% to 87.5% under the same pH change. This indicates that such resins do possess strong adsorption capacity and can adapt to a wide range of adsorption conditions. 2. Selectivity of hydrogen bond adsorption resins Studies have shown that hydrogen bond adsorption resins synthesized as donor-type, acceptor-type, or hybrid types possess strong adsorption selectivity. The (-OH) type has good adsorption properties for caffeine, the receptor type (-C=O) can separate aniline, N-**amines, and N,N-di**amines, while the mixed type (-CNHCOR or -NHCONH-) can simultaneously adsorb xanthones and lactones. All these results can be explained by the hydrogen bond adsorption mechanism. 3. Applications of hydrogen bond adsorption resins Significant results have been achieved in the separation of traditional Chinese medicine components using the aforementioned hydrogen bond adsorption resins. Mixed resins are used to extract flavonoids and lactones from ginkgo leaves, with yields of over 40%, which is twice as high as when ordinary resins are used. Another type of hydrogen-bonding resin can also completely separate xanthones and lactones, yielding two pharmaceutical components in high concentrations. Resins of this type are highly effective for separating alkaloids such as camptothecin, vinca alkaloids, and caffeine. Research has shown that hydrogen-bond adsorption resins can be used for the extraction and separation of most active components in traditional Chinese medicines, such as flavonoids, saponins, alkaloids, and esters, making them a key separation technique for the \"modernization of traditional Chinese medicine\".
Go to Baidu first, and then read relevant books! :L
Regular bookstores carry books on this subject: He Binglin’s \"Ion Exchange and Adsorption Resins\" is excellent!