On the hydrolysis of nitriles
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Currently, in most hydrolysis processes, liquid alkali is added first, and then acid is used to convert the resulting sodium salts into their acidic form. I’m not sure if there’s a one-step method that can directly hydrolyze nitriles into acids
It seems everyone isn’t very interested in this post, so I’ll upvote it myself. There are reports that acidolysis using concentrated sulfuric acid or high-pressure hydrolysis can be employed; I wonder if anyone has experience with such experiments.
It depends on which nitrile you are hydrolyzing; dilute sulfuric acid or phosphorous acid can both be used, but the cost needs to be taken into consideration.
Iminodiacetonitrile – I wonder if there is a good way for its hydrolysis.
Currently, iminodiacetonitrile is also produced by first hydrolyzing it to its sodium salt and then acidifying it to yield iminodiacetic acid; it will likely take industrial testing to determine whether the new method is effective
It is said that sulfuric acid can be used, but the effect is likely to be inferior to that of alkaline hydrolysis
Dear experts, 1: Could the loss of nitrile groups occur during alkaline hydrolysis?