What to do in case of phenol and 2,4,6-trichlorophenol poisoning?
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What to do in case of phenol and 2,4,6-trichlorophenol poisoning? What specific drugs are used for detoxification? How to use it? In which books, or on what websites, specifications, or standards should I look up information? Also, please do not tell me the information listed on the MSDS; that information is too general and vague, and it isn’t very useful in cases of actual poisoning. The company’s medical office needs to have antidotes for each type of material on hand. If the doctors there are unable to handle a situation, it falls to our Safety and Environment department. I need detailed information. Thank you
Treatment plan for phenol poisoning (please refer to http://baike.baidu.com/view/1333353.htm): 1. Carefully insert a soft gastric tube, and wash the stomach repeatedly with vegetable oil until the washings no longer have a phenol odor; then leave 60 ml of vegetable oil in the stomach. Even if a long time has passed since the poisoning, gastric lavage should not be abandoned. 2. After gastric lavage, inject 60–80 ml of 30% sodium sulfate. 3. Areas of the skin and oral mucosa that have come into contact with phenolic substances should be thoroughly rinsed with warm water, and then cleaned using soapy water, ethanol, or oils. 4. Comatose patients can be given oxygen therapy, antibiotics to prevent infection, and intravenous infusions of 5% glucose solution and normal saline to prevent circulatory failure, reduce kidney damage, and facilitate the elimination of toxins. For those with acidosis, sodium bicarbonate can be used. When blood pressure drops, transfusion and appropriate use of vasopressors are given.
One may refer to the book edited by Ren Yijin and Zhang Shoulin; currently, specific antidotes are mainly used for symptomatic treatment. Additionally, phenol is classified as a nephrotoxic substance, and the treatment principles related to this may be useful
Correction: Refer to Ren Yinjin and Zhang Shoulin as editors; currently, there is no specific antidote, and treatment is mainly symptomatic.
Phenol: Skin contact: Immediately remove contaminated clothing, wash the affected area with glycerin, polyethylene glycol, or a mixture of polyethylene glycol and alcohol (7:3), and then rinse thoroughly with water. Or rinse with plenty of flowing water for at least 15 minutes. Seek medical attention. Eye contact: Immediately lift the eyelids and rinse thoroughly with plenty of flowing water or saline for at least 15 minutes. Seek medical attention. Inhalation: Quickly move to a place with fresh air. Keep the airway clear. If there is difficulty breathing, administer oxygen. If breathing stops, perform artificial respiration immediately. Seek medical attention. Ingestion: Immediately administer 15–30 mL of vegetable oil. Induce vomiting. Seek medical attention. 2,4,6-Trichlorophenol: Skin contact: Immediately remove contaminated clothing and rinse with plenty of flowing water. Seek medical attention. Eye contact: Lift the eyelids and rinse with flowing water or saline. Seek medical attention. Inhalation: Quickly move to a place with fresh air. Keep the airway clear. If there is difficulty breathing, administer oxygen. If breathing stops, perform artificial respiration immediately. Seek medical attention. Ingestion: Drink plenty of warm water and induce vomiting. Seek medical attention.