Crystal state issue! ! !
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We have an intermediate that forms needle-shaped crystals when precipitated in methanol solution; it is difficult to increase the solid content during centrifugation. If granular crystals could be formed, then the solid content could definitely be increased. Are there any ways to change the state of the precipitated crystals? This post was last edited by hwqckr on 2009-3-10 22:49]
By controlling the low supersaturation, the crystal particles become larger and the crystal grains remain more intact.
It is recommended to use other solvents for crystallization if conditions permit!
It’s done using freezing; I’m not sure if that will work
Adjust the stirring speed and method, cooling rate, etc
Reduce the cooling and crystallization time. Reducing the speed is also an option for aging; however, aging will delay the production cycle
First, try to create some seeds using other methods on your own, then add those seeds to the methanol solution; avoid centrifuging and instead try freezing it to lower the temperature
Add some surfactants to reduce the surface energy, or use other solvents for crystallization