Urgent problem with product clarity!!!!
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Our company mainly produces APIs, and the clarity issues of several new varieties have been bothering us recently. All other indicators are passable, but the clarity is unstable and feels uncontrollable. Even increasing the number of refining passes (refining by recrystallization) has no effect. I don’t know why, but several varieties have this problem. Sometimes the opalescence is unqualified, and sometimes it's cloudy. I don't know whether this is an engineering problem or a process problem of each product. If anyone is interested, please discuss it, thank you!!
Maybe the solution is not stable enough. . It is mainly caused by incomplete reaction or excessive content of certain ingredients.
This doesn't seem to be an engineering problem, right? But I don’t understand your medical stuff, so let’s take a guess! The quality of your previous products was fine, but there is a problem with the new product. Is it possible that it is a problem with your process? Poor clarity, does it mean your product solution system is unstable? Are the components inside unstable? Or is it a matter of solubility changes? I don’t know if it is feasible to analyze Kazakhstan from these aspects.
Product clarity is a difficult issue. In the production of chemical reagents, we often encounter such problems. Simple recrystallization rarely solves the problem. You can consider adding activated carbon filtration.
I think there are three points: One, the process is not very mature and needs to be improved. Second, it is the equipment to see if it meets the operational requirements. three: Do the external conditions meet your production needs? I think medicine should be carried out in a dust-free and pollution-free environment! The above is my personal opinion, I hope you can give me some advice!
Clarity For organic extraction, there may be water-in-oil droplets in the extraction solution, causing the clarity to not meet the standard. Adjusting the concentration of demulsifier to eliminate water-in-oil droplets is one way to solve the problem of clarity. ,
1. Ensure the raw materials are qualified first. 2. Check the process. The temperature control point is more important. There is no need to check the equipment. 3. If this happens to a few batches, find a way to deal with it. If it happens frequently, you should check it carefully. We have also experienced this phenomenon, and the result appears in the temperature.
Is it the product after crystallization? If so, please take a look at the following opinions. The transparency of the product is insufficient. It should be that the crystallization conditions are not good. If the impurities in the product are not easy to remove, small particles may condense on the crystal surface at the end of the crystallization, resulting in poor surface transparency. Therefore, it is necessary to test to see where the crystallization termination temperature is. It is best to consider adding surfactants to improve this phenomenon, but this needs to be tried.
Our products also have clarity problems, don’t know how to solve them?