HCBBS Forum (English)
Submit Chemical Projects / Find Solutions
Amplify Your Requirements on a Broader Chemical Platform *Engineering · Technology · Equipment · Solutions*
Submit Request

What are some common reagents in organic synthesis?

2009-02-28View Original

Thread Content

I would like to ask everyone: what are some of the commonly used reagents in organic synthesis that are relatively expensive? Sodium borohydride is one example, but tetrahydrofuran is not!
Reply #22009-02-28
Hexamethylenetetramine, tert-butyl aluminum, alkyl lithium, alkyllithium aluminum, alkyl zinc, and alkyl tin are all sufficient
Reply #32009-02-28
In fact, in the process of organic synthesis, whether something is expensive or not is relative; regarding the impact of a particular raw material or reagent on the cost of the final product, one factor is its price, and another is its consumption per unit! For example, the catalysts used in certain reactions are quite expensive, but the amount required is relatively small and they can be reused, so the overall cost isn’t that high. I have gained a deep understanding of this, as it is very important when screening the synthesis processes for a certain product. Last year, I worked on a product, and sodium borohydride mentioned by the original poster was used in the restoration process. Although its unit price might be relatively high, its proportionate cost is not that significant; in many cases, it is the solvents that are used in large quantities that require the most attention. If methanol can be used, ethanol should not be used; if 95% ethanol is available, anhydrous ethanol should definitely not be used... If heptane mixtures can be used, n-heptane should definitely not be used. But considering the price, many chiral reagents are quite expensive!
Reply #42009-03-01
This is a very broad topic. In my opinion, to obtain good experimental results, the quality of reagents is crucial; sometimes it’s necessary to use imported reagents, which are much more expensive, but they yield satisfactory results. Using domestic reagents may not produce any results at all, which is even more wasteful. I recommend a book titled \"Modern Organic Synthesis Reagents – Properties, Preparation, and Reactions\", edited by Hu Yuefei and others. It was published by the Chemical Industry Press on July 1, 2006, with a price of ¥78.00. The book selects commonly used reagents based on their academic and practical value in modern organic synthesis, enabling readers to quickly and comprehensively understand the properties and applications of these reagents.   It has a reasonable structure, clear hierarchy, rich content, and prominent key points. It introduces the physical and chemical properties, preparation methods, and safety precautions for each reagent. The applications of 365 reagents in organic synthesis reactions were discussed in detail. On average, more than 5 representative and original reaction examples are selected for each reagent. Each reagent is accompanied by an average of over 10 authoritative and original references. This book is suitable for teachers and students in chemistry and related fields at colleges and universities as a learning resource and reference. It is also intended for scientific researchers and technical personnel in research institutions and enterprises working in related areas. Table of Contents: List of Reagents (sorted by Pinyin) (R)-(-)-2-Amino-2-phenylethanol (S)-1-(a-aminobenzyl)-2-naphthol Aminosulfonic acid Palladium-barium sulfate Palladium-calcium carbonate-lead acetate Benzene sulfonyl chloride (-)-8-Phenylprenol Phenylmethyl-di(tricycliphosphine)-ruthenium dichloride Phenylmethyl-p-di-(tricycliphosphine)ruthenium Phenylmethyltribenzylphosphane Phenylboronic acid Phenylglycolic acid 1,4-Benzoquinone Pyridine p-toluenesulfonate 2-Pyridone 2-Pyranobenzene Lithium benzylate Magnesium benzyl chloride Benzyl(chloromethyl) ether Bromobenzene Benzoyl chloroform B-propanolide Diethyl malonate Methacryloylboronic acid Propynenecyanide Diethyl propylphosphonate Allyl ethyl ether Dimethyl deuteromalonate Diethyl deuteromethylphosphonate Deuteromethane Ethyl deuterooctanoate Dichromopyridinium salt Potassium dichromate Ozone Hypofluoric acid-acetonitrile complex Sodium hypochlorite Palladium acetate Mercury acetate Lead acetate Copper acetate Monoisopropylborane Iodine Sodium iodide Samarium(II) iodide Zinc iodide Methyl iodide Iodobenzene 2-Iodobenzoic acid Azidotrimethylsilane Ethyl oxymalonate Sodium azide 2,3-Butanediol 1,3-Butadiene n-Butyllithium s-Butyllithium p-Toluenesulfonyl azide p-Toluenesulfonyl methyl isocyanate p-Toluenesulfonyl chloride
Reply #52009-03-02
It’s absolute experience: another way to cut costs is to speed up the project timeline, as labor costs are also quite significant. Reagent costs are generally not under your control.
Reply #62009-03-04
There are too many reagents; different products require different reagents. Are you asking about solvents, OP? Will this be helpful to you? It doesn’t seem to deserve discussion either; it would be better if you could tell me what kind of product you’re working on

Submit a Project

**Looking for Chemical Technology, Equipment & Solutions?** No Registration Required Broader Platform Exposure | Global Chemical Service Provider Connections

Submit Request — Free Consultation

Disclaimer

This is an automated machine translation of the original thread. Some technical terms may have inaccuracies; the original text shall prevail. Click "View Original" at the top right to access the source page, which supports IP-based automatic real-time language translation. Please watch out for contact details and sales inducements to prevent fraud. All content and translations are for reference only, representing solely the poster's personal views. For enquiries, email service@hcbbs.com.