Pyridine base production process

Development status of pyridine base industry Pyridine base is a nitrogen-containing heterocyclic common compound. It is the key common compound of pesticides, pharmaceuticals, veterinary drugs, and other three drugs and their intermediates. It is an important raw material for daily chemicals, feed, food additives, and radial tire industries. It is also a key intermediate for toxic intermediates and toxic production processes of alternative environmentally friendly pesticides such as imidacloprid, chlorpyrifos, and paraquat. Pyridine base mainly comes from chemical synthesis and coking by-products. Currently, more than 98% of it comes from chemical production. Our country currently does not have industrialized equipment with independent intellectual property rights, and the pyridine base needed domestically depends entirely on foreign imports. Up to now, pyridine base has been monopolized by companies such as Lonza of Switzerland and Rayleigh of the United States for more than 50 years. 　　Pyridine bases are mainly used in pesticides, medicines, feed additives, food, medicinal vitamin PP, daily chemicals, tire industry and other fields. In terms of pesticides, it can produce more than 30 kinds of products, such as paraquat, diquat, chlorpyrifos, imidacloprid, etc. ； In medicine, more than 50 varieties can be synthesized, such as sulfa, penicillin, vitamins, omeprazole, lansoprazole, cortisone, etc. ； In veterinary use, it is the main raw material for the production of feed additives niacin and nicotinamide. ； In the daily chemical and tire industries, it can be used in anti-dandruff shampoos, fungicides, dyes, coatings and radial tire industries. Pyridine base can be made into a variety of intermediates through chlorination, fluorination, ammonia oxidation, etc., and is widely used in the field of fine chemicals. According to preliminary statistics, global annual sales of pyridine base manufactured products amount to approximately US$50 billion. 　　As of 2007, the global demand for pyridine base was approximately 125,000 tons, while the actual production capacity was only about 80,000 tons. Analysis of global usage demand of pyridine bases: At present, more than 70% of pyridine is mainly used for pesticide synthesis, and more than 85% of 3-methylpyridine is mainly used for the production of feed additives and vitamin PP (nicotinamide) ； 90% of 2-methylpyridine is used in the production of pesticides and radial tires. However, with the advancement of science and technology, environmental protection requirements and the needs and changes of the company's proprietary technology and cost reduction, the uses of pyridine bases will undergo fundamental changes in the future. 　　my country currently still uses the traditional coal tar separation method with high energy consumption and high impurities on a small scale, with a production capacity of less than 200 tons/year. In 2001, a new pyridine base production unit with an annual output of 11,000 tons was put into operation in a joint venture between the American Reilly Company and Nantong Acetic Acid Chemical Plant. So far, there is still no industrialized device with independent intellectual property rights in China. It still relies entirely on imported pyridine bases from abroad. The research on foreign pyridine base synthesis technology is concentrated in companies such as Mobil, Reilly, Nepera, Lonza, and Koei. my country's Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Shanghai Petrochemical Research Institute, Dalian University of Technology, Zhejiang University and other research institutions have also successively carried out research. Although some patents have been formed, they are still far away from industrialization and there is no device for industrial production.

To supplement the above, China has now developed high-level catalysts on its own, and some companies have introduced foreign technology. Nanjing Red Sun 1W tons and Anhui Red Sun 2.5w tons pyridine base projects have been put into production, and Nantong Ruili 1w has also been put into production.； Daqing 1w tons and Sanonda 1w tons are currently bidding. Generally speaking, domestic pyridine alkali projects are receiving more and more attention, and the development speed should make a leap in recent years.

There are still very few talents in the field of pyridine! This year is 2017, and the information I found on the forum all said it was from 2009. It seems that the development speed in this area is not too fast, and the technology is not very mature yet!

Does anyone have any information related to pyridine bases and can they share it?