Dioxane hydrochloride

Properties and preparation/purification of common reagents in organic chemistry: Dioxane has a boiling point of 104.5°C and a density of d = 1.0336. It is miscible with water, colorless, flammable, and can form an azeotrope with water (81.6% composition, boiling point of 87.8°C). It generally contains a small amount of diethanol acetal along with water; 10% concentrated hydrochloric acid can be added and the mixture can be refluxed for 3 hours while nitrogen is slowly introduced to remove the acetaldehyde that is formed. After cooling, granular potassium hydroxide is added until it no longer dissolves; the aqueous layer is separated, and the mixture is then dried with granular potassium hydroxide for one day. Filter, add metallic sodium and reflux for several hours, then distill. Prolonged storage of dioxane may result in the formation of peroxides, which should be removed before further processing.

A six-membered heterocyclic compound containing two oxygen atoms. Molecular formula C4H8O2. Also known as di?alkane. Flammable liquids. Melting point: 11.8°C, boiling point: 101°C (750 mmHg), relative density: 1.0337 (20/4°C). Soluble in water and organic solvents such as ethanol and ether. 1,4-Dioxane, similar to ethers, can form peroxides; it must be treated with a reducing agent during distillation. 1,4-Dioxane can be prepared from ethylene glycol through dehydration with sulfuric acid; it is also an indirect product in the production of ethylene oxide. 1,4-Dioxane is an important solvent that can be used as a solvent for cellulose acetate and many resins. Its vapor is irritating to the mucous membranes. As shown in the figure

Toluene and xylene are added to concentrated sulfuric acid for a reaction, followed by the addition of p-toluenesulfonic acid, methanol, alcohol, and water to carry out further reactions. Could isopropanol and dioxane be among the reaction products? ? ?