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Organic synthetic chemistry and route design--Ju Yong, Zhao Guohui,* Edited by Chanjuan Introduction to the content This book is a textbook written for organic chemistry courses for undergraduate and graduate students in the University Department of Chemistry. The main content has two aspects: First, on the premise that students have mastered basic undergraduate organic chemistry, various types of organic chemical synthesis reactions, such as oxidation reactions, reduction reactions, cyclization reactions, heteroatom insertion reactions, and a large number of practical reactions in the application of elemental organic compounds, are introduced and discussed to enrich students' knowledge of organic synthesis reactions and technologies. ； The second is to introduce and discuss thinking methods and techniques in organic synthesis route design, such as disassembly of target molecules, retrosynthetic analysis, synthon and polarity conversion, introduction of inducing groups, simplification of synthetic routes, etc. On this basis, the important strategies of synthetic design by Corey, an expert in contemporary organic synthesis route design, are also introduced. At the end of the book, several complex organic target compounds are taken as examples to discuss their total synthesis routes. This book is written by Associate Professor Ju Yong and Professor Zhao Guohui, Key Laboratory of Organophosphorus Chemistry, Ministry of Education, Department of Chemistry, Tsinghua University, * Written by Associate Professor Chanjuan. They have rich practical teaching experience in the fields of teaching and research, and collected a large number of latest reference materials when writing this book. Readership: Undergraduates and graduate students in university chemistry departments and scientific and technical personnel engaged in organic synthesis. Contents 1 Introduction 1 Purpose and tasks of organic synthesis 2 Development status of organic synthesis 3 Modern achievements of organic synthesis 4 Development trends of organic synthesis 2 Basic knowledge of organic synthesis and route design 1 Key points of organic synthesis 2 Basic methods of organic synthesis route design 3 Selectivity and control of organic synthesis reactions 3 Disassembly of molecules 1 Prioritize the formation of skeleton 2 Disassembly methods and points of attention of molecules 3 Disassembly of alcohols 4 Decomposition of B-hydroxycarbonyl compounds and a, B-unsaturated carbonyl compounds 5 Decomposition of 1,3 dicarbonyl compounds 6 Decomposition of 1,5 dicarbonyl compounds 7 Decomposition of a-hydroxycarbonyl compounds 8 Decomposition of 1,4 and 1,6 dicarbonyl compounds 9 Synthesis of lactones 10 Comprehensive training * 4 Introduction of directing groups 1 Activation is the main means of guiding 2 Passivation of guides 3 Use of blocking specific positions for guidance 5 Synthons and polarity conversion 1 Basic theory about synthons 2 Specific applications of synthon polarity conversion 3 Classification and addition of synthons 4 Methods of synthon polarity conversion 5 Commonly used methods for polar conversion 6 Oxidation reactions 1 Oxidation of alcohols 2 Oxidation of aldehydes and homologs 3 Oxidation of carboxylic acids 4 Oxidation of alkenes 5 a-Oxidation on carbon atom 6 Oxidation at non-active site 7 Reduction reaction 1 Catalytic hydrogenation 2 Metal hydride reduction 3 Metal reducing agent 4 Low-valent metal salt reducing agent 5 Non-metal reducing agent 8 Protecting group 1 Protection of hydroxyl group 2 Protection of diol 3 Protection of carbonyl group 4 Protection of carboxylic acid 5 Protection of amino group 9 Cyclization reaction 1 Overview of cyclization reactions 2 Diels-Alder reaction 3 1,3 dipolar cycloaddition reaction 4 Addition of carbene and nitrogen to alkenes 5 Electrocyclization ring closure 6 Ring opening 10 Synthesis of organic compounds containing heteroatoms 11 Application of phosphorus, sulfur and silicon in organic synthesis 12 Simplification of synthesis problems 13 Introduction to Corey's five major strategies for organic synthesis route design 14 Examples of total synthesis of natural products References This book is indexed by commonly used abbreviations Chinese index English index http://www.brsbox.com/filebox/down/fc/07b8a9c3c97538d39646e38a889d333f