Which acetonitrile synthesis process has the lowest cost?

Acetonitrile synthesis is suitable for large-scale chemical manufacturing; ordinary companies should not consider it

Agree with what was said above; the production cost of acetonitrile is high, so it is generally used in large enterprises

Producing acetonitrile by synthetic methods is a speculative approach, as once the economy improves and acrylonitrile production facilities come online, such synthetic methods will definitely be too costly. Additionally, the costs of the ethanol amination method and the acetic acid amination method are similar; in both cases, molten salts are used for heating, and care must be taken regarding safety in this process

I know that there are two methods for producing acetonitrile: via ethanol and ammonia oxidation, and by ammoniating acetic acid to form amides followed by dehydration to obtain acetonitrile. However, I’m not aware of the costs involved

The cost of producing acetonitrile from acetic acid and ethanol is around 20,000 yuan each

What was said upstairs is too high; after calculation, the cost of producing acetonitrile through ethanol ammonolysis does not exceed 12,000.

This falls under the category of large-scale chemical manufacturing; it’s impossible to make a profit if production levels don’t increase! Below are all the production methods for acetonitrile: There are many methods for producing nitriles, and the main ones used in industrial production are the ammoniation of acetic acid ； Acetylene amination method and propylene ammoxidation by-product method, etc. 　　1. The ammoniation acetate method uses acetic acid ； Using ammonia as a raw material, acetonitrile is synthesized in one step under the action of an alumina catalyst at a temperature of 360–420°C. The reaction mixture is then processed through water absorption and distillation to yield the final product. Raw material consumption quota: Acetic acid (98%) 1763 kg/t ； Liquid ammonia (99.5%) 691 kg/t. 　　2. The acetylene amination method uses acetylene ； Acetonitrile is synthesized in one step using ammonia as a raw material and an aluminum oxide catalyst at a temperature of 500–600°C. Raw material consumption quota: Acetylene 10,231 m3 ； Liquid ammonia (99.4%) 1007 kg/t. 　　3. The propylene amin oxidation by-product method uses propylene ； When acrylonitrile is synthesized from ammonia and air using a catalyst, acetonitrile is produced as a by-product. 25-100 kg of acetonitrile can be produced as a by-product per ton of acrylonitrile. 　　4. Obtained by the dehydration of acetamide and phosphorus pentoxide. 　　5. Obtained by the reaction of dimethyl sulfate with sodium cyanide. Among the methods mentioned above, only the first one is the most competitive; the others are not very viable and constitute speculative approaches.

The price of acetonitrile has dropped significantly; discussing this post now holds no economic value. However, even speculative behavior has its merits. It is advisable to use acetamide to produce acetonitrile; I have a friend who synthesizes acetamide from glacial acetic acid and then proceeds with dehydration to obtain acetonitrile, without the need for any molten salts. Although the current price of acetonitrile is now lower than his production costs, self-sufficiency in the past ensured demand for acetonitrile for other applications. Such speculative behavior doesn’t aim to challenge the scale advantages of large companies, but it does help prevent firms from being overwhelmed by the high costs of acetonitrile.

Acetonitrile produced as a by-product of acrylonitrile is not comparable to synthetically produced acetonitrile; by-products remain by-products, and their production volume is greatly limited.