Anisole production
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Do you have any information on the production process of anisole and its main operating parameters? Thank you!
I’m not sure which route you’ll take; currently, the most cost-effective approach is the dimethyl sulfate methylation route. However, you need to consider the issues related to the purchase and transportation of dimethyl sulfate, as it is a highly toxic substance.
Generally, it is achieved by reacting phenol with dimethyl sulfate
I wonder which one the original poster wants? Could you explain it in more detail? Hello, I’m here to help you… :)
It’s a relatively simple manufacturing process, or the commonly used production workflow nowadays; it would be better to be a bit more specific.
We use the dimethyl sulfate route for production, as the factory next door produces dimethyl sulfate; however, the technology is a secret and cannot be disclosed! ! !
First, phenol is added to a sodium hydroxide solution to form sodium phenoxide. Then, dimethyl sulfate is gradually added at a temperature below 10 degrees, after which the temperature is raised to 40 degrees and the mixture is allowed to reflux for 18 hours； After the reaction is complete, the oil layer is separated, dried with anhydrous calcium chloride, and the final product is obtained through vacuum distillation!
Dimethyl sulfate has quite a few environmental problems, right?
Should we go with benzaldehyde instead? Profits are good these days.
The anisole production expansion project I was involved in also involved phenol, liquid alkali, and dimethyl sulfate; dimethyl sulfate was added drop by drop in a reaction that involved the methylation of the phenolic hydroxyl group. However, it has not yet been determined whether dimethyl sulfate acts as a methylating agent with one or two methyl groups participating in the reaction. Post-treatment is achieved by extracting the organic phase in layers and then distilling it in a distillation tower.
This stuff produced as a by-product in PC production via non-phosgene methods