How can the impurities generated during the preparation process of glycine amide hydrochloride be removed?
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How can the impurities generated during the preparation process of glycine amide hydrochloride be removed? The possible impurity is ammonium chloride; so how can glycine amide be separated from ammonium chloride? :( I hope someone from HaiChuan University can offer some guidance – I’d be very grateful! ! !
Ammonium chloride decomposes easily; a slight heating is sufficient. However, you’ll need to check on your own whether your glycine amide deteriorates at the decomposition point of ammonium chloride.
Glycine amide hydrochloride also changes color and deteriorates when heated. Are there any other more effective and reasonable methods?
It can be extracted using a solvent; try methanol
Ammonium chloride has a low freezing point; try using crystallization to remove it.
Solvent crystallization is likely the most effective method for removing impurities