How to calculate the optimal cooling procedure for cooling crystallization
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I read in industrial crystallography that there is an optimal cooling procedure for batch operations, but I don’t know how to calculate it? Please tell me!
This is determined based on the crystallization law of the crystallized material system during the crystallization process, that is, based on the crystallization requirements, the supersaturation control requirements of the crystallization process are determined, and the optimal operating curve is determined.
How to calculate a theoretical value? Thanks
The book "Crystallization Process" may be useful.
I think the book Crystallization Technology is very useful.
The best cooling program should be the best cooling curve. When the supersaturation generated after the temperature of the crystallization liquid decreases per unit time is equal to the supersaturation consumed by crystal growth during this period, the supersaturation of the crystallization liquid remains at a constant level. The cooling rate at this time is called the optimal cooling curve. All calculations of the theoretical optimal curve require knowledge of the solubility of the crystallization system at different temperatures, crystal growth rate, average crystal particle size and number of crystal grains. The theoretical value calculation process is very complicated and lacks practical application significance. Generally, the optimal cooling curve is explored through experiments, so that the data obtained are both simple and realistic.