Monoethanolamine
Thread Content
Monoethanolamine, a chemical. Monoethanolamine is primarily used for buffering purposes and in the preparation of emulsions in pharmaceutical formulations. Additionally, the most common therapeutic use of this product is as an oleic acid mon ethanolamine injection, used as a tissue sclerosing agent. Monoethanolamine: Alternative name Monoethanolamine ； Ethanolamine ； colamine ； Ethylolamine CAS NO. 141-43-5 Category of additive: Alkalinizing agent ； The use of emulsifiers in pharmaceutical formulations or formulation processes. Other applications include: serving as solvents for fats and oils ； As a stabilizer for phenytoin glucose solution for injection. Monoethanolamine can also be used to prepare various salts with therapeutic uses. For example, the monoethanolamine salt of vitamin C can be used for intramuscular injection, while the monoethanolamine salts of salicylic acid and elaeic acid can be used respectively to treat rheumatism and as antifungal agents. Properties: This product is a clear, colorless or pale yellow liquid with a slight ammonia odor and moderate viscosity. General properties: Relative molecular mass: 61.08; pH: 12.1 (0.1 mol/L aqueous solution); Boiling point: 170.8°C; Critical point: 341°C; Density: 1.01179/cm3 at 25°C, 0.99989/cm3 at 40°C, and 0.98449/cm3 at 60°C; Dissociation constant: pKa = 9.4 at 25°C; Flash point (closed cup method): 93°C; Hygroscopicity: Highly hygroscopic; Melting point: 10.3°C; Refractive index: n(D20) = 1.4539; Solubility: Solubility in solvents at 20°C – Propanone: miscible; Ethanol: miscible; Benzene: 1:72; Chloroform: miscible; Ether: 1:48; Glycerol: miscible; Methanol: miscible; Water: miscible. Stability and storage conditions: Monoethanolamine is highly hygroscopic and unstable when exposed to light. Aqueous solutions can be sterilized by heat pressure. When storing large quantities of monoethanolamine, stainless steel containers are preferable for long-term storage. Copper, copper alloys, zinc, and galvanized iron containers can all be gradually corroded by amines; therefore, these materials should not be used to manufacture storage containers. Monoethanolamine readily absorbs moisture and CO2 from the air ； It can also react with CO2. Isolating the inert gas from monoethanolamine can prevent these reactions from occurring. A smaller amount of monoethanolamine should be placed in a light-proof, airtight container and stored in a cool, dry place. Incompatibilities: Monoethanolamine contains hydroxyl and amino groups, which allows it to undergo reactions typical of alcohols and amines. This product can react with acids to form salts and esters. In the presence of heavy metal salts, it changes color and precipitates. This product reacts with acids, anhydrides, acyl groups, and esters to form amide derivatives, and with propionic acid or other cyclic carboxylic acids to form corresponding carbonates or esters. Monoethanolamine has a primary amine group that can react with aldehydes or similar compounds to form iminal and imine compounds. Furthermore, monoethanolamine can form complex salts with aluminum, copper, and copper alloys. It reacts violently with acraldehyde, vinyl cyanide, epichlorohydrin, lactone, and vinyl acetate. Safety Monoethanolamine is irritating and corrosive ； Although there have been reports of allergic reactions to this product, it generally does not cause adverse reactions when used in neutral injectables and topical preparations. Generally speaking, the toxicity of monoethanolamine salts is lower than that of monoethanolamine. Operational precautions When handling concentrated solutions of monoethanolamine, personal protective equipment should be worn. Such as appropriate masks, chemically resistant gloves, safety glasses, and other protective clothing. The transfer or preparation of monoethanolamine can only be carried out in a chemical fume hood. Monoethanolamine vapor can drift along surfaces to distant ignition sources and then return to its original location. A sealed container exposed to heat may explode. Contact with strong oxidizers may cause a fire. In the UK, the short-term (15 minutes) occupational exposure limit for monoethanolamine is 15 mg/m3 (6 ppm), while the long-term exposure limit (8-hour TWA) is 7.6 mg/m3 (3 ppm). Regulations: It is approved in the UK and the US for use in both injectable and non-injectable formulations.
Name: Ethanolamine
English name: 2-Aminoethanol, Colamine
Abbreviation: MEA
Other names: 2-Aminoethanol
Chemical formula: C2H7NO/H2NCH2CH2OH
Molecular weight: 61.1
Relative density (water): 1.018
Auto-ignition temperature (°C): 410
Melting point (°C): 10.3
Viscosity (mpa·s): 18.9 (25°C)
Vapor relative density (air): 2.11
Explosion limit (%): 5.5–17
Flash point (°C): 93
Solubility in water: Highly soluble
Saturated vapor pressure (kPa): 0.053 (20°C)
Maximum allowable concentration (mg/m3): 15
Boiling point (°C): 170.8
Material for storage and transportation equipment: CS(B)
Appearance and properties: Colorless, hygroscopic, viscous liquid with an ammonia odor; miscible with water, and soluble in ethanol, ether, chloroform, and various other organic solvents. It is moderately to strongly alkaline. Storage safety requirements dictate that fire and explosion prevention measures be in place when storing in tanks. Open-air storage tanks require cooling measures in summer. It must be stored separately from oxidizers, acetic acid, acetic anhydride, and acrylonitrile. When stored in barrels, they should be kept in a cool and well-ventilated area, away from sources of fire and heat, protected from direct sunlight, and the containers must remain sealed. Loading, unloading, and transportation require gentle handling to avoid collisions. For safe operation, open flames are prohibited at the site during tank filling; mechanical equipment and tools that may generate sparks must not be used. The filling flow rate should not exceed 3 m/s, and a proper grounding system is required. Hazardous characteristics of the goods: 1. Flammable; at temperatures above 85°C, its vapors can form explosive mixtures with air, and it can catch fire or explode in the presence of open flames or high heat. Contact with oxidizers and similar substances can cause combustion or explosion. Toxic fumes are produced when burning. 2. Toxic. Direct contact with its liquid or vapor can cause poisoning, irritate the skin and eyes, affect the central nervous system, and lead to changes in blood composition and tissue damage. 3. At 20°C, this substance evaporates quite slowly, and it takes a long time for its concentration in the air to reach harmful levels. 4. It will erode rubber, copper, aluminum, and their alloys. Personal protective measures: 1. Protective clothing, gloves, goggles, and face shields must be worn during operations. In high-concentration environments, a self-contained breathing apparatus should be worn. 2. In the event of accidental contact with its liquid, remove the contaminated clothing, rinse the skin and eyes thoroughly with plenty of water, move to an area with fresh air, and then seek medical attention. Spill handling: 1. Collect the spilled liquid in a sealed container and neutralize it carefully. 2. Rinse away the residues with plenty of water, and spray misty water to remove the vapor. 3. Wear chemical protective clothing and a full-face air respirator during handling. Firefighting and emergency measures: 1. In the event of a leak, the fire source must be brought under control immediately, and relevant personnel should be evacuated. 2. Fire extinguishing methods: fog water, alcohol-resistant foam, dry powder, carbon dioxide. 3. In case of a fire, spray water to keep the material tanks and others cool.
English name: 2-Aminoethanol, Colamine
Abbreviation: MEA
Other names: 2-Aminoethanol
Chemical formula: C2H7NO/H2NCH2CH2OH
Molecular weight: 61.1
Relative density (water): 1.018
Auto-ignition temperature (°C): 410
Melting point (°C): 10.3
Viscosity (mpa·s): 18.9 (25°C)
Vapor relative density (air): 2.11
Explosion limit (%): 5.5–17
Flash point (°C): 93
Solubility in water: Highly soluble
Saturated vapor pressure (kPa): 0.053 (20°C)
Maximum allowable concentration (mg/m3): 15
Boiling point (°C): 170.8
Material for storage and transportation equipment: CS(B)
Appearance and properties: Colorless, hygroscopic, viscous liquid with an ammonia odor; miscible with water, and soluble in ethanol, ether, chloroform, and various other organic solvents. It is moderately to strongly alkaline. Storage safety requirements dictate that fire and explosion prevention measures be in place when storing in tanks. Open-air storage tanks require cooling measures in summer. It must be stored separately from oxidizers, acetic acid, acetic anhydride, and acrylonitrile. When stored in barrels, they should be kept in a cool and well-ventilated area, away from sources of fire and heat, protected from direct sunlight, and the containers must remain sealed. Loading, unloading, and transportation require gentle handling to avoid collisions. For safe operation, open flames are prohibited at the site during tank filling; mechanical equipment and tools that may generate sparks must not be used. The filling flow rate should not exceed 3 m/s, and a proper grounding system is required. Hazardous characteristics of the goods: 1. Flammable; at temperatures above 85°C, its vapors can form explosive mixtures with air, and it can catch fire or explode in the presence of open flames or high heat. Contact with oxidizers and similar substances can cause combustion or explosion. Toxic fumes are produced when burning. 2. Toxic. Direct contact with its liquid or vapor can cause poisoning, irritate the skin and eyes, affect the central nervous system, and lead to changes in blood composition and tissue damage. 3. At 20°C, this substance evaporates quite slowly, and it takes a long time for its concentration in the air to reach harmful levels. 4. It will erode rubber, copper, aluminum, and their alloys. Personal protective measures: 1. Protective clothing, gloves, goggles, and face shields must be worn during operations. In high-concentration environments, a self-contained breathing apparatus should be worn. 2. In the event of accidental contact with its liquid, remove the contaminated clothing, rinse the skin and eyes thoroughly with plenty of water, move to an area with fresh air, and then seek medical attention. Spill handling: 1. Collect the spilled liquid in a sealed container and neutralize it carefully. 2. Rinse away the residues with plenty of water, and spray misty water to remove the vapor. 3. Wear chemical protective clothing and a full-face air respirator during handling. Firefighting and emergency measures: 1. In the event of a leak, the fire source must be brought under control immediately, and relevant personnel should be evacuated. 2. Fire extinguishing methods: fog water, alcohol-resistant foam, dry powder, carbon dioxide. 3. In case of a fire, spray water to keep the material tanks and others cool.