Sample separation
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When a distillate decomposes easily when heated or has a too high boiling point, can vacuum distillation be used to separate the sample?
If distillation is to be used, vacuum distillation should be employed; other separation methods can also be considered.
If distillation separation is to be used, vacuum distillation is the only option; it is also a method that requires lower costs and less operational effort compared to other separation methods. Other properties of the separated components can also be taken into consideration, such as their solubility in different solvents; solvent extraction can be employed, as well as crystallization at various temperatures to achieve further separation. For some chiral compounds, separation can also be achieved using chiral derivatives. If there are significant differences in the retention properties on the adsorbent, preparative chromatography columns can also be used for separation.
The 3rd floor provides a comprehensive overview; as an additional point: when the distillate is prone to decomposition when heated or has a too high boiling point, it is necessary to consider the boiling points, boiling ranges, polarity, and approximate contents of each component in the material, and make a comprehensive assessment.