How to remove isomeric impurities
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A new product was recently developed successfully; it is a liquid whose purity, after vacuum distillation, is only 97%, whereas the required purity is over 99%. The main issue is that there is a small peak of about 3% remaining after the main peak, and this is an isomer formed as a side reaction. The boiling points of the product and this impurity differ by only 5 or 6 degrees, so it’s not possible to increase the purity any further beyond 97%. Is there anyone who can solve this problem? A fee will be set. It is also possible to carry out the purification process on behalf of us; we will cover the costs.
There are many methods, but it is necessary to know exactly what substance it is, look up its relevant physical properties, and then remove it accordingly!
How can I get in touch with you? Could we discuss this in more detail?
Do you need to specify exactly what substance is to be separated? There are so many isomers, and naturally different methods are used for separating different substances; distillation and extraction are quite common methods!
tert-Butylbenzene? This can only be removed through reaction; distillation makes it difficult to separate? What chromatography column do you use?
What thing? Distillation definitely enables separation; it’s just a matter of operating costs. If needed, we can discuss this in more detail.
One can try using acidic ion exchange resin as a catalyst to carry out the transposition reaction at a certain temperature.
It was originally created through transposition; if transposed again, there will be even more