Changes in load, as well as changes in pressure and temperature.
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Do the controlled temperature and pressure change at 50% and 100% load of the reactor? Do the controlled temperature and pressure change when the distillation tower is operating at 50% and 100% load?
Small differences are acceptable; large differences are not allowed
Of course there are changes, especially in distillation columns. Under different loads, the temperature at the bottom of the column is controlled differently; otherwise, the proportion of the product extracted will change, and as a result, the composition will also change!