Hydrogen chloride generated in the Fuchs acylation reaction can easily cause the target product to rearrange; what methods can be used to remove it promptly?
Thread Content
Hydrogen chloride generated in the Fuchs acylation reaction is detrimental to the main product, as it can easily cause the main product to rearrange; what are good ways to remove hydrogen chloride promptly during the experiment? The literature mentions using triethylamine as an acid scavenger; I wonder if triethylamine reacts with anhydrous aluminum chloride? Will it affect the effectiveness of the catalyst?
We used nitrogen purging, and the effect was significant