What solvents are insoluble in toluene?
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I have currently synthesized a product in toluene. Due to the product’s very high boiling point, it cannot be purified by distillation. It is planned to separate it from toluene using extraction. The first thing that comes to mind is water. However, this product has a low solubility in reclaimed water, and it also becomes somewhat unstable after being in water for an extended period of time. Which other solvents are insoluble in toluene?
The answer is upstairs. Are there any organic solvents that are immiscible with toluene?
After distilling off most of the toluene, the product-rich liquid at the bottom of the column is recrystallized for purification.
Thank you to everyone above. Since there are heavier components in toluene as well, it’s impossible to separate them by distilling out the toluene. Therefore, we have no choice but to resort to extraction and crystallization methods. Thank you!