Does the Fuchs reaction fall under the category of hazardous processes that are subject to strict regulation?
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There is a Fuchs acylation step in the production process; could you please check whether it falls under the alkylation processes that are considered high-risk processes subject to strict regulation?
In my personal opinion, the Fuchs acylation reaction should not be classified among the 18 hazardous chemical processes. Fuchs alkylation falls into that category mainly because the alkylated products formed are more susceptible to being replaced by the alkylating agent; it is a multi-step reaction, and poor control over it can lead to intense local reactions.
The chlorination process used in hazardous chemical manufacturing should be referenced, with chlorine oxide serving as the chlorinating agent.
Do you think it belongs to the chlorination process? But the chlorine atom isn’t added directly to the reactants; I don’t think that’s likely.
Do you think it belongs to the chlorination process? But the chlorine atom isn’t added directly to the reactants; I don’t think that’s likely.
Based on the molecular formula of the reaction product you provided, a chlorine atom is attached to the side chain of the reactant molecule. Therefore, the chlorination process in hazardous chemical processes should be referred to.
The aforementioned acylation reaction is neither an alkylation reaction nor a chlorination reaction, and it is not a hazardous process that falls under strict regulatory control as listed in 18
This post was last edited by Zhou Jianxing on 2020-7-1 09:47. Hello, original poster. We have a Fuchs acylation reaction similar to yours; originally, the safety assessment did not classify it as a hazardous reaction. However, during the evaluation by the expert panel, it was recommended to classify this as a hazardous reaction, and it was suggested that an oil bath be used for the jacket. So if strict requirements apply in your case, it’s better not to take any chances. Also, may I ask about the conditions for this reaction of yours right now? Our substrates are different, but our acyl chloride structure is the same ； I added the substrate, dichloromethane aluminum trichloride, to the reaction vessel, then added the acyl chloride at low temperature. After addition was complete, hydrolysis was carried out using 1 mol/L hydrochloric acid; the yield was only 90%, which seems quite low. I’m not sure what the reason for this is! ! !
Our company has basically not been classified as operating under hazardous processes; some experts bring this up during evaluations