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The hazards of a process system usually stem from the risks posed by the chemicals involved and the process itself (process technology and process equipment). It is of great significance for safe production to comprehensively collect all information related to the hazards of chemicals, as well as process and equipment aspects involved in the production process. Process safety information should include details on the properties of the chemical materials involved in the production process (such as raw materials, auxiliary materials, intermediates, products, by-products, heat transfer media, sealing fluids, and substances resulting from deviations in process conditions), information on process thermal hazards, as well as data related to the processes and equipment used. It is difficult to carry out safe production work without having comprehensive information on it. Comprehensive and accurate process safety information forms the basis for enterprises to manage safety in production. Managers and operators can use this information to understand the hazardous properties of materials, the risk points in the production process, and the operational requirements of equipment, thereby taking appropriate safety measures to prevent accidents. For example, by understanding the chemical properties of raw materials, storage and transportation methods can be planned appropriately to avoid accidents caused by the characteristics of those materials. With the advancement of science and technology, new chemical substances are continuously synthesized, and the hazards of these new substances remain unclear. For chemicals whose hazards are unknown, a physical hazard assessment should be conducted. In the chemical production process, certain chemicals may be encountered whose hazards are not yet clear. By conducting physical hazard assessments, it is possible to accurately determine the hazardous properties of these chemicals, such as flammability, explosiveness, and toxicity, thereby providing a basis for the safe use, storage, and disposal of these chemicals. This helps companies improve their process safety documentation, enhance their management of chemicals, and reduce safety risks associated with unknown hazards of those chemicals. To fully understand the process safety information, a comprehensive thermal risk assessment should be conducted for the production processes involving nitration, covering various materials, different process steps, process types, and reactor types. To assess the possibility of decomposition explosions caused by thermal runaway in the nitration process, it is also necessary to evaluate abnormal operating conditions that could lead to significant changes in the process thermal risk parameters. When there are changes to the process, a process hazard analysis of the process and the equipment should be conducted, taking into account the results of thermal risk assessment, in order to develop and implement safety risk control measures ; When process parameters such as system temperature, material ratios, feeding sequence, and feeding rate change, a thermal risk assessment must be conducted again. Of course, relevant management personnel and staff in the relevant positions should be well aware of process safety information. Only when employees are aware of process safety information can they handle materials and operate equipment correctly in practice, and identify and address potential safety risks in a timely manner. Companies should use methods such as training and assessments to ensure that employees have a thorough understanding of process safety information, thereby enhancing their safety awareness and operational skills, so that this information can truly play its role in ensuring production safety.