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From December 21st to 22nd, the Fourth Modern Agricultural Development Forum was held in Yichang, Hubei. Zheng Yuguo, an academician of the Chinese Academy of Engineering and dean of the School of Biotechnology at Zhejiang University of Technology, pointed out that biomanufacturing can fundamentally transform traditional manufacturing models, promote the deep integration of biotechnology with the production of important industrial products such as pharmaceuticals, pesticides, materials, and food, and facilitate a shift in economic development toward a green, low-carbon, non-toxic, and sustainable model. Biomanufacturing helps drive the transformation and upgrading of the manufacturing industry and gives rise to new business models. Firstly, it promotes green development by reducing energy and material consumption in industrial processes, minimizing waste emissions and pollution of water, air, and soil, significantly cutting production costs, and enhancing the competitiveness of industries. Secondly, it promotes low-carbon development by replacing traditional high-carbon processes with green production models, thereby contributing to the achievement of the \"dual carbon\" goals. Third, promote circular development, optimize the efficiency of natural resource and energy utilization, and achieve the recycling of materials, hierarchical conversion of energy, as well as a positive interaction with the ecological environment. Biomanufacturing is regarded as a force that can drive the “Fourth Industrial Revolution,” and it is a key area for accelerating the development of new forms of productivity. In the field of pesticide biomanufacturing, by leveraging theories and methods from various disciplines such as biology and engineering, biomanufacturing technologies can help reduce carbon emissions during the pesticide production process, as well as increase efficiency and reduce the amount of pesticides used. With policies encouraging the use of low-toxicity pesticides, nicosulfuron has become one of the key crops for promotion, and 2-chloronicotinic acid is a critical intermediate in its synthesis. Innovations in the synthesis pathway of nicosulfuron can be promoted through multi-unit coupling technologies such as chemical-enzymatic catalysis and reactions, as well as separation and purification. Imidazolinone herbicides are widely used to control weeds in crops such as soybeans, rice, and wheat. By thoroughly understanding the molecular mechanisms underlying the catalytic activity of nitrile hydratase and developing strategies for the precise design and modification of this enzyme, it is possible to significantly reduce the discharge of inorganic salts and nitrile-containing wastewater, thereby highlighting the green benefits of biomanufacturing. The total chemical synthesis of L-aminopropylphosphonic acid faces challenges such as difficulties in achieving chirality, low selectivity, and high costs. In contrast, the chemical-enzymatic method for synthesizing L-aminopropylphosphonic acid offers advantages such as high enzyme activity, strong selectivity, and good stability; it can significantly reduce the environmental burden and is in line with the Ministry of Agriculture and Rural Affairs’ policy goal of reducing pesticide use while improving their effectiveness. As a new type of \"industrial revolution,\" synthetic biology manufacturing is profoundly transforming the ways in which materials are produced. It will bring about significant innovations in terms of raw materials, manufacturing processes, and product characteristics, accelerating the development of new forms of productivity and thus providing strong support for the sustained and rapid growth of the national economy.