Layout of the material feeding room
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In the workshops for active pharmaceutical ingredients or intermediates, it is sometimes necessary to use materials with high activity or high toxicity. Is it required to have a dedicated feeding area for adding such materials during sampling or solid feeding, or are there any specific design guidelines?
There should be a professional feeding protection device next to the reactor!
Feed material into a confined space – should the confined space be ventilated separately from the workshop? Or what?
It’s necessary! And this enclosed space must not have any connection to the outside world at all!
So can I set up a material extraction room in the workshop to extract multiple types of materials, or can the extraction room I set up only be used for extracting a single hazardous material?
A dedicated feeder can be used, along with a glove box or isolator
Use an isolator with negative pressure and passivation; remember to inactivate it after use. The filter should be designed with a BIBO configuration
For the hermetically sealed automatic feeding equipment in the kettle, the pipelines used to transport the material are connected to the workshop’s ground wire, thereby dissipating the static electricity associated with the material； First, the material is drawn into the equipment and then discharged into the reaction vessel; simultaneously with this discharge, nitrogen is blown in to increase the amount of inert gas inside the vessel, thereby preventing accidents. The sealed automatic feeding equipment for reaction vessels replaces manual feeding of powders and solid particles into the reactors. It is connected to the reactors via sealed flexible connections, which prevents dust from being generated during feeding; this improves the utilization rate of materials. The sealed connection between the equipment and the reactors also stops organic solvents from leaking out of the reactors. Feeding is fast and efficient, thereby reducing the workload on employees. The equipment is controlled by a PLC; programs are developed based on the actual production requirements of the customer. It can be connected to the workshop’s DCS control system, allowing the workshop to monitor the equipment’s operating status as well as control its start and stop. It has been put into use in the production of the pesticide active ingredient thiacloprid, replacing the manual addition of oxadiazine and ultra-fine potassium carbonate to the reaction vessel.