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Atom economy and the 5\"R\" principles are the core elements of green chemistry technologies. The 5\"R\" principles refer to Reduction, Reuse, Recycling, Regeneration, and Rejection, while atom economy involves making full use of each atom in the reactants, thereby enabling efficient utilization of resources and preventing pollution. The use of biocatalytic technology can significantly improve atom economy. In the development of chemical processes, green chemistry techniques employ non-toxic reactants and catalysts, strive for atom economy, and minimize additional waste products during reactions in order to make full use of the reaction materials. In chemical reaction processes, most chemical reactions require a catalyst to take place. The production of catalysts is often even a process that causes environmental pollution. Therefore, developing environment-friendly catalysts is a very important direction. Biocatalysis refers to the process of chemical transformation using enzymes or biological organisms (whole cells, organelles, tissues, etc.) as catalysts, and is also known as biotransformation. Biocatalysis (enzymes) is commonly used to prepare molecules with two or more chiral centers, or to produce intermediates that cannot be selectively chemically transformed from simple precursors. Green chemistry technologies can utilize chemical techniques and methods to reduce or eliminate the generation and use of raw materials, solvents, reagents, products, by-products, etc., that are harmful to human health or the environment. Medici’s Process Development Department is primarily involved in the research and development, process optimization, and large-scale production of preclinical new drugs, newly launched active pharmaceutical ingredients, generic drugs, as well as intermediates that meet GMP standards. Medici integrates the concept of \"green chemistry\" into the exploration and design of processes as well as into production workflows, incorporating enzyme chemistry and continuous reaction technologies into process synthesis. Furthermore, in the exploration of synthetic routes, Medici also tries to avoid high-temperature and high-pressure reaction conditions as well as the generation of toxic waste, thereby putting green chemistry into practice in its design approach. " Enzyme-catalyzed processes generally offer advantages such as short processing times, few reaction steps, and low levels of by-products. Enzymes and biocatalytic techniques have become established technologies in the chemical and pharmaceutical industries for the production of various chemicals. Biocatalytic technology boasts excellent stereoselectivity, chemical and regioselectivity, as well as mild reaction conditions. It enables the avoidance of side reactions such as isomerization, racemization, and rearrangement that occur in traditional synthesis. Moreover, it reduces the use of harmful heavy metals and excessive metal catalysts, as well as organic solvents used as reaction media and for the separation and purification of products, thereby significantly improving atom economy and reducing the environmental impact of the process. Biocatalytic technology has accelerated the development of green chemistry technologies, and it represents one of the key trends in the advancement of green chemistry and green chemical engineering. To minimize the impact on the environment and processing costs, it is considered based on atom economy, along with the total cost of reagents and production efficiency. Sometimes, the most atom-economical reagents exhibit poor physicochemical or toxicological properties, or lack the desired reaction selectivity or reactivity. Therefore, when selecting reagents, all subsequent impacts must be taken into account. The advantage of biocatalytic technology is that it can be carried out in water, at room temperature, with few or no protecting groups ； The main disadvantages are low reaction stability, high cost, sometimes poor stereoselectivity, and low reaction concentration. The reactions of some enzymes can also take place in organic solvents. Currently, the utility of biocatalytic technology in the pharmaceutical and chemical industries is continuously expanding, and it holds broad application prospects and market potential in the development of green chemistry technologies and biocatalytic processes for active pharmaceutical ingredients.