How to choose the addition rate for the esterification reaction
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Reactor A undergoes esterification with methanol, and thionyl chloride is also added; my understanding is that A reacts with methanol to form an ester, while thionyl chloride does not participate in the reaction but acts as a catalyst. So, is it better to add methanol to the reaction mixture to control the reaction, or to add thionyl chloride to control the extent of the reaction?
This post was last edited by *amingteda on 2022-9-1 10:38. Excess A or methanol can be considered, with the other reactant being added dropwise. Sulfoxides are more often used as solvents, serving to create a reaction phase/interface
Based on the chemical reaction equation provided, both reactant A and methanol are involved in the reaction; in other words, it’s acceptable to add either reactant A or methanol, is that right? For example, if thionyl chloride is used as a catalyst, wouldn’t it be ineffective to add thionyl chloride gradually in order to control the extent of the reaction? Or in other words, it wouldn’t work at all. Thank you!
I’ve never heard of mixing two reactants first and then adding a catalyst to initiate the reaction. There is no reaction at the beginning or the reaction is slow; won’t the reaction become intense all of a sudden after adding a large amount of catalyst? First, add the catalyst and one reactant; the other reactant is added while the reaction takes place, which makes it easier to control
Thank you so much for answering my questions; really!
The catalyst dosage needs to have a sensitivity point identified
The sulfoxide should form an acyl chloride with your carboxylic acid, and then the carboxylic ester is produced with methanol. Add some DMF to act as a catalyst.
Got it, thank you so much! :)