Separation of isomers with a boiling point difference of 2°C
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Hello, experts. Our factory is facing a separation challenge that needs to be resolved: it involves 3-chloro-o-xylene and 4-chloro-o-xylene, with the ratio of 3-position to 4-position being 45:55； The boiling points of these two substances differ by very little; the boiling point of the 3-position compound is around 194°C, while that of the 4-position compound is around 192°C. They are all data at atmospheric pressure. The melting point data is unknown. In this case, is it feasible to use distillation for separation? You can contact me. Thank you!
There is virtually no feasibility. . . . . . . .
At high temperatures, thermal decomposition is also required; distillation is not the first choice
Melting point: -42 VS -6; separation can be achieved through melt crystallization, as distillation is not feasible for this purpose
Thank you for the reply! The boiling point data for these two substances is hard to find, and the few values that are available vary significantly from each other.
Thank you for the reply! The melting point data for these two substances is also difficult to find; only the data for 3-chloro is available, while for 4-chloro, some sources indicate -6°C while others state that the data is unavailable. Let’s wait for experimental verification. Thank you!
It is possible to separate this using conventional distillation; more than 100 theoretical plates are required, and vacuum operation is necessary. Contact within the site is possible
The extractive distillation method can be tried.