Centrifugal extractor | Extraction tank | Extraction column – three-step extraction method for penicillin

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Extraction equipment is widely used in the pharmaceutical industry. The three-step extraction process for obtaining penicillin using such equipment is quite mature. This extraction process takes advantage of the fact that penicillin salts (sodium and potassium salts) are soluble in water, while penicillin acid is soluble in organic solvents; by repeatedly transferring the substance between the solvent phase and the aqueous phase, purification and concentration are achieved. The three-step extraction method using extraction equipment for penicillin: In the first step, penicillin in the extraction equipment is transferred into the organic solvent by acidifying the filtrate with dilute sulfuric acid ； In the second step, penicillin is transferred from the organic solvent to the aqueous phase using phosphate buffer or an aqueous solution of sodium bicarbonate ； In the third step, dilute sulfuric acid is added to the penicillin buffer extract, and extraction equipment is used to transfer penicillin from the aqueous phase into the organic solvent. After concentration and purification, it can be sent to the crystallization process. With the improvement of extraction equipment. Centrifugal extractors that utilize multi-stage counter-current extraction and separation within the same machine can **reduce the number of equipment units required**. Those in need can go to http://www.cncuiqu.com and give it a search