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This post was last edited by gaoshun on 2016-2-25 09:33. In my work, I occasionally need to look up data on acute toxicity. Perhaps it’s because of my limited knowledge, but in such a large country as China, with so many government agencies and numerous standards, I haven’t found a single standard that provides detailed information on the LD50 and LC50 values for common substances. The 2015 version of the hazardous substances catalog provided categories but no detailed data. The Ministry of Health’s list of highly toxic substances specifies the occupational exposure limits. GB5044 and GBZ230 only provide classification methods; GB5044 also gives examples, while GBZ230 does not provide any examples at all. Some MSDS are provided, but their authority is unclear. Wikipedia does mention that the United States has a database on the toxicity of chemical substances called RTECS, but it is available only for a fee. I understand that accurate LD50 and LC50 values need to be determined through repeated experiments; however, for common substances, **specific values can be provided in appendices to facilitate access by companies and individuals. For substances that are not common or that are specific to certain companies, those companies must conduct the tests themselves or commission them to others.
I have not come across information regarding the sources of values such as LD50 and LC50. However, based on my own work experience, for example, when we look at the safety data sheets for certain hazardous substances, the LD50 and LC50 values indicated there are determined through tests on rats via oral administration and mice via dermal exposure. There are significant differences among human beings, and specifying the LD50 and LC50 values for each substance might be impractical in terms of workload and implementation; that’s why such values are not provided. As a result, the Ministry of Health has established occupational exposure limits in its list of highly toxic substances, providing a warning value for those working in related industries.