How to dry drug substances containing crystalline water
Thread Content
How to dry drug substances containing crystalline water, keeping the temperature at 20°C, and how to carry out vacuum drying using an oven. (The tray oven) It has been found that after drying, there is no more crystalline water left!
First, it is necessary to determine the temperature conditions at which the material contains crystalline water; evaporation occurs within this temperature range
In addition to paying attention to the drying temperature, attention should also be paid to the drying time. For any substance containing crystalline water, there is always a balance between deliquescence and weathering, with the humidity in the gas phase having a particularly significant impact. If drying is to be used, it is recommended to first conduct a thermogravimetric analysis on the drug to determine the dehydration temperature. Additionally, the drying time should be controlled; even if drying is carried out for an extended period at temperatures below the dehydration temperature, some or all of the crystal water may be lost due to weathering.
If there’s really no other way, I’ll solve it for you. But I need to consider the properties of the material. Simulation is still needed. Recently, at several factories in Hunan, Shaanxi’s Weinan, and Shanxi’s Ruicheng, I was dealing with issues related to wastewater and exhaust gas treatment, as well as drying processes.