Solution via distillation extraction of amine compounds
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I am currently distilling an extract from the fermentation broth; its boiling point at atmospheric pressure is 190 degrees Celsius. During direct vacuum distillation, water will definitely emerge first, followed by amines, and finally an aqueous solution of amines. Is there any way to obtain a high-concentration amine product directly? Except for the following points. Concentrating the fermentation broth at low temperature followed by distillation can increase the amine concentration; this has already been done. It can also be achieved using a distillation tower, but it seems like an overuse of resources; since there’s only one target product, isn’t it unnecessary?
Do you mean to extract first, then remove the solvent, and finally obtain the product? In that case, the purity of the product won’t be as high as that achieved through distillation, right?
The separation of amines from water is usually achieved through extraction; if their polarity is very high, acidification and concentration followed by distillation are the only options
Thank you. First, acidification and concentration are carried out, followed by alkaline distillation; the concentration of the amines obtained through distillation does not reach 80–90%, so further concentration is required, which involves using three evaporators in total. If the stock solution is not concentrated and is distilled into vapor before being fed directly into the middle of the distillation column, with ammonia at the bottom of the column and water at the top, is this feasible?
The final amine concentration after entering the distillation tower can’t be guaranteed to be very high either; it may still need to be concentrated. It mainly comes down to which device has a lower cost of investment
I haven’t tried distillation of aromatic amines; it should be possible, but the relative volatility of polycarbon amines to water isn’t very high, which may require a tall distillation column. In the past, low-boiling-point petroleum ether was used for extraction; you can give distillation a try. Amines tend to produce many impurities when heated excessively. . . . . For amines concentrated to 8-90%, you can use sodium sulfate or calcium oxide for dehydration and filtration
May I ask, how common is the issue of materials entering the distillation tower? Is preheating sufficient, or is it necessary to first convert the amines and water into steam before feeding them into the tower?
May I ask, how common is the issue of materials entering the distillation tower? Is preheating sufficient, or is it necessary to first convert the amines and water into steam before feeding them into the tower?
{:2_30:} I was busy conducting experiments, so I didn’t spend much time on it. The laboratory setup usually involves a flask, along with a distillation column and a reflux condenser. For pilot-scale testing, it’s necessary to have someone calculate the appropriate feeding point; the feed is generally supplied at saturated conditions, and it’s fine if the temperature is a bit low. Theoretical requirements are quite strict, but in practice those requirements aren’t so high – as long as the product produced is of satisfactory quality, that’s sufficient. If not, adjustments can be made